A new strategy to rule-out and rule-in heart attacks in emergency departments will help physicians treat patients faster, found a clinical trial published in CMAJ (Canadian Medical Association Journal).
Acute myocardial infarction (MI) is a common cause of death and disability around the world. Early diagnosis is critical for treatment and survival.
Swiss and Spanish researchers conducted a clinical trial to determine whether a new technique, previously tested in a small pilot study, would be effective in determining whether a patient has had a heart attack. They enrolled 1320 patients who visited the emergency department with suspected acute MI and applied the high-sensitivity cardiac troponin T 1-hour algorithm to blood samples.
“Introducing the high-sensitivity cardiac troponin T 1-hour algorithm into clinical practice would represent a profound change and it is therefore important to determine if it works in a large patient group,” states Dr. Tobias Reichlin, Division of Cardiology, University Hospital Basel, Switzerland.
With the algorithm, the researchers were able to determine that 786 (60%) of patients did not have an acute MI (“rule-out”), 216 (16%) were “rule-in” and 318 (24%) were to be observed because results were not conclusive.
“This rapid strategy incorporating high-sensitivity cardiac troponin T baseline values and absolute changes after the first hour substantially accelerates the management of patients with suspected acute MI by allowing safe rule-out as well as accurate rule-in of acute MI in 3 out of 4 patients,” the authors conclude.
Story Source:
The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.
Journal Reference:
- Christian Mueller et al. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ, April 2015 DOI: 10.1503/cmaj.141349