The Barcelona Institute for Global Health (ISGlobal) represents the accumulation of three decades of experience in this specialty. Barcelona’s Hospital Clinic established Spain’s first tropical medicine unit in 1984, and two decades later, in 2006, the Barcelona Centre for International Health Research (CRESIB) was founded. CRESIB became part of the new ISGlobal Institute founded in 2010. ISGlobal has a structure that focuses on research, training, education, think tank, and technical cooperation.